Lupus miliaris disseminatus faciei (LMDF) is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly. A biopsy specimen revealed epithelioid cell granulomas with central necrosis, consistent with a diagnosis of lupus miliaris disseminatus faciei (Figure 2). Lupus miliaris disseminatus faciei (LMDF) first described in is an uncommon dermatosis of unknown etiology with characteristic.

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National Center for Biotechnology InformationU. Seven of the patients presented with solitary lesions only, which resulted in a differential diagnosis including epidermal cyst, basal cell carcinoma, and indurated actinic keratosis.

It presents with pale papules which may be confused with sarcoid or syringoma clinically. Lupus miliaris disseminatus faciei — The DNA of Mycobacterium tuberculosis is not detectable in active lesions by polymerase chain reaction.

Sir, Lupus miliaris disseminatus faciei LMDF is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly localized on the face.

Lupus miliaris disseminatus faciei LMDFfirst described by Fox inis a rare granulomatous inflammatory dermatosis that mostly affects young adults. Lupus miliaris disseminatus faciei LMDF is a granulomatous eruption characterized by monomorphic, reddish-brown papules and nodules predominantly localized on the lupsu.

Therefore, only the fully developed lesions subclassified as sarcoidal epithelioid granuloma with central caseation necrosis are represented in our sample. Histopathological examination of a skin biopsy taken from a representative lesion on the chin revealed dermal epithelioid cell granulomas, miliaeis with central areas of necrosis, and surrounding moderate lymphohistiocytic infiltrate with multinucleate giant cells, mostly of the Caciei type Figure 2.

Various treatments have been tried with tetracyclines, isotretinoin, dapsone, prednisolone, clofazimine, isoniazid and corticosteroids, with variable results. Report of a new case and brief literature review.

Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. Spontaneous resolution of the lesions is reported to occur over years, often leaving small, pitted scars [ 1dissemintus6 ].


Clin Exp Dermatol ; Guidelines Upcoming Special Issues. The presence of nuclear dust and neutrophils within the zones of caseation necrosis suggests that neutrophils may indeed play a role in inducing this change [ 9 ].

The clinical presentation of LMDF has classically been described as multiple, smooth, mm brown-red, brown, to yellowish dome-shaped papules to nodules distributed symmetrically on the central and lateral face and around the eyelids, more often involving the lower eyelids [ 1 – 5 ].

Lupus miliaris disseminatus faciei pathology | DermNet NZ

In our study of 10 patients, we have found clinical presentations that vary from the classic description of LMDF. J Clin Exp Dermatol Res 5: Lupus miliaris disseminatus faciei.

Diascopy may reveal apple-jelly nodules [ 1 – 3 ]. Open in a separate window.


Please review our privacy policy. Improvement in lesions after dapsone therapy Click here to view. Clinical features reviewed included age of patient, location and number of lesions, duration, description of primary lesion, size, and suspected clinical diagnosis or differential diagnosis.

Support Center Support Center. Lulus Online J ; Faciiei X-ray was unremarkable. Epithelioid granulomas have been experimentally produced by intradermal injection of sebum and comedones [ 19 ].

The granuloma formation could be regarded as a reaction to breakdown products of the pilosebaceous unit such as keratin and sebum or to antigens exposed during follicular rupture [ 41018 ].

Complete resolution of skin lesions was noted by the third treatment. Indian J Dermatol Disswminatus Leprol ; Microscopic findings are essential for diagnosis and characteristically reveal superficial granulomatous inflammation surrounding caseation necrosis that is often perifollicular in distribution, although LMDF is now regarded as a spectrum classified into three histological stages: Lupus miliaris disseminatus faciei LMDFmorphea, tuberculosis.

The clinical diagnosis or differential diagnosis at time of biopsy included basal cell carcinoma BCC in six cases and sarcoidosis, granuloma annulare ,upusand epidermal cyst in two cases each. He works in biscuit wrapper manufacturing unit; but there is no history of contact with any chemical or fumes. Is ‘lupus miliaris disseminatus faciei’ still an acceptable diagnosis in the third millennium?


Create a free personal account to make a comment, download free article PDFs, sign miliris for alerts and more. The exact etiopathogenesis of LMDF remains unknown. Lupus miliaris disseminatus faciei LMDF is an uncommon but distinct, chronic, inflammatory dermatosis characterized by abrupt development of generally asymptomatic, single to multiple, mm brown-red, brown, to yellowish dome-shaped papules or nodules with occasional mild scaling [ 1 – 5 ].

The disseminatuz lesions are located on the face, where the density of pilosebaceous units is highest. Pharmaceutical Sciences Journals Ann Jose ankara escort. No scarring or pigmentary alterations were associated with treatment. Extrafacial involvement in LMDF has been rarely reported in the literature. On examination, multiple, erythematous, firm papules and nodules of size ranging from 0.

One patient presented with a solitary lesion of the lower back with no facial involvement and another presented with a solitary lesion of the antihelix without facial lypus. Ann Jose ankara escort. Lupus Miliaris Disseminatus Faciei: Additionally, dissseminatus can be distinguished by physical examination, chest X-ray, and laboratory tests, and infectious disorders by the absence of microorganisms detected through histochemical stains PAS, Ziehl-Neelsen.

Sarcoidosis is considered to be a cell mediated granulomatous disease. One lesion had a centrally located pustule, and one had slight scaling.

This left few, if any, established treatments for her condition, which remained active. Further information is needed to clarify the diagnosis, etiology, and dissemibatus of this disease, but an unusual host response to folliculitis or follicular injury likely plays a idsseminatus in most cases. With such an approach, a wide variety of granulomatous disorders might qualify for inclusion, including granulomatous rosacea, granulomatous perioral dermatitis, acneiform folliculitis, and a number of cutaneous infections.

Another proposal is that LMDF may be a reaction to an as-yet unknown infectious agent associated with cell-mediated immunity [ 12 ].