;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.

lazy leukocyte syndrome

Autosomal dominant new mutations. Both random mobility and chemotactic function were defective.

The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve.


Lazy leukocyte syndrome.

A characteristic abnormality of actin distribution in neutrophils was demonstrated. While lazu OMIM database is open to ssyndrome public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.

Expert curators review the literature and organize it to facilitate your work. Transient ‘lazy-leukocyte’ syndrome during infancy. We need long-term secure funding to provide you the information that you need at your fingertips.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

Leukocyte phagocytosis and bactericidal activity were normal. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. Clinical Synopsis Toggle Dropdown. Pathology of chemotaxis and random mobility. Skin window mobilization test and chemotaxis were normal. A poor leukkocyte response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique.


Please consider making a donation now and again in the future. Unfortunately, it is not free to produce. A new disorder of neutrophil function. The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. Mobilization of leukocytes after exercise was defective.

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Miller knew of 4 other cases. Looking For More References? Single cases were reported by Costanopoulos et al.

Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. A severe neutropenia was found. None is syndrpme and no parental consanguinity is known.