Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .
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Open in a separate h;mc. However, the release was higher in 0. Oral controlled release formulations of rifampicin. Particle size and size distribution exerted more than one effect, and its influence on melt suspension viscosity was not straightforward. Lai Wah Chan, Phone: Multivariate methods in pharmaceutical applications.
National Center for Biotechnology InformationU. Therefore, to ensure a higher productivity rate and a product of consistent quality, it is essential to employ an analytical tool capable of evaluating the viscosities of polymer melt suspensions.
The results alluded that E15 LV did not exhibit particle-particle interaction. Further, the statistical analysis of the drug release profiles was carried out by one-way analysis of variance ANOVA and by comparing the drug release profiles using a model-independent method Spray-congealed microparticles for drug delivery—an overview of factors influencing their production and characteristics.
In matrix devices, the drug is homogeneously dispersed in either a hydrophobic or hydrophilic polymer matrix. Air was extracted from the chamber by an hpmx fan. Hmpc, the present study aimed at the design of isoniazid CR formulations by using relatively simple manufacturing technology which can be easily adopted in industrial units on a commercial scale.
Hypromellose – Wikipedia
In the later hours also, the release rates remained similar, as initial porosity has no effect on the release from the swollen tablet matrix.
Twin screw extruder equipment. Sustained release isoniazid tablets. The formulations were found to be stable and reproducible. Effect of microfluidization of heat-treated milk on rheology and sensory properties of reduced fat yoghurt. Ophthal Plast Reconstr Surg. They exist in different viscosity grades, containing different percentages of methyl and hydroxypropyl substitutions Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity.
Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M
Typically, this critical congealing temperature is inversely related to both the solution concentration of HPMC and the concentration of the methoxy group within the HPMC molecule which in turn depends on both the degree of substitution of the methoxy group and the molar substitution. This article has been cited by other articles in PMC.
Expert Opin Drug Deliv. The reason for higher HPMC release in 0. The correlation between the viscosity profiles obtained using the rheometer hmpc the PCA scores plot was employed to establish the suitability of PCA as an analytical tool for classifying the viscosity profiles of melt suspensions. Berry M, Schott N.
Three hhpmc of each formulation were prepared and their quality and respective release characteristics were evaluated under the same conditions as prescribed in previous sections. Fickian and anomalous hpcm from swellable devices. Such analysis would also provide useful information on the possibility of substituting one HPMC grade with another without affecting the manufacturing process and final product.
Above that viscosity, choking problems occurred. Rheology and processing of polymeric materials: Melt of PEG alone had the lowest viscosity among the formulations.
Principal component analysis has been applied in the pharmaceutical industry to detect differences in production batches when process k4k changed 18evaluate characteristics of excipients 1920 and assess effects of formulation parameters on granule and tablet properties 2122 and in the non-pharmaceutical industries 23 — The influence of excipients on drug release from hydroxypropyl methylcellulose matrices.
Four distinct groups of viscosity profiles obtained using the rheometer were observed. Smaller particles led to a greater viscosity than larger particles. Formulations jpmc the low viscosity clusters 0.
The Einstein coefficient depends on the geometry o4m orientation of the entities that make up the dispersed phase, e. Therefore, it is harder for longer chains to dissolve because of the high energy required for pulling them off the matrix. Metronidazole MNZ k4n included as the model drug, as most pharmaceutical formulations contain at least one active pharmaceutical ingredient.
The authors declare no conflict of interest. Conventional statistical method, such as analysis of variance ANOVAallows the comparison of each data point to other points at a particular temperature.
However, molar substitution is also often expressed in percentages. Hence, E15 LV would be the most appropriate grade to use when a need for high HPMC concentration, yet maintaining a suitable viscosity, is required.
It is likely that the variation in the particle shapes of the different HPMC grades affected particle-particle interactions to a certain extent. Formulated tablets were subjected to the following physical characterization studies.