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Of individuals initially randomized to treatments, 22 were finally removed from the dataset because it was verified they did not fully meet inclusion criteria or removed proper written consent during the first week.

Amazon Inspire Digital Educational Resources. The role of premorbid personality and social cognition in suicidal behaviour in first-episode psychosis: I’d like to read this book on Kindle Don’t have a Kindle?

The Lancet Psychiatry 4: First-episode psychosis patients on quetiapine were more likely to discontinue treatment due to nonefficacy. Predicting suicidal behaviour after first episode of non-affective psychosis: Privacy Policy Terms and Conditions.

Consequently, we found statistically significant differences between aripiprazole and quetiapine and between ziprasidone and quetiapine but not between aripiprazole and ziprasidone, where we only found a trend towards nondiscontinuation favoring aripiprazole. Please choose whether or not you want other users to be able to see on your profile that this library is a favorite of yours.

Curr Opin Psychiatry There’s a problem loading this menu right now. All treatments decreased at least 4 points on the CGI scale from baseline to 3 years Table 3.

Limitations and Strengths Several limitations should be considered when interpreting our results. Home About Help Search. This was a prospective, randomized, flexible dose, open-label study. Your request to send this item has been completed. Thus, the final sample consisted of subjects: Higher risk of all-cause treatment discontinuation in facofro patients had already been described during early phases of treatment Ciudad et al. Intention-to-treat analysis revealed that The profile of motor side effects varied between treatments, as did the ability of each group to adhere to treatment.


Citations are based on reference standards.

María Juncal-Ruiz – Semantic Scholar

Survival time could be censored by the end of the observation period or by loss to follow-up patients who dropped out before discontinuation of the initial treatment.

Effects of previous suicide attempts and depression Lopez-Morinigo, J-D. Linked Data More info about Linked Data. However, there were no statistically significant differences in the use of benzodiazepines between the aripiprazole group and the ziprasidone group Optimal doses of antipsychotics within the licensed range were chosen based on clinical efficacy and the presence of side effects and were adjusted according to the clinical situation of each patient. The finding of no significant differences between treatment groups regarding the decrease in these clinical efficacy scales and responder rates agrees with previous reports McEvoy et al.

ComiXology Thousands of Digital Comics. All patients included in the analysis had at least the baseline and 3-year assessments and were considered for drop-out in those cases in which they did not attend 2 consecutive check-point assessments. Read more Read less.

Finally, most aripiprazole discontinuations were due to nonadherence Per-protocol analysis showed rather similar results data available upon request. In summary, guaranteeing good adherence to effective antipsychotic treatment is one of the main challenges in the treatment of FEP individuals to prevent a malignant course of the disease.

A rapid titration schedule 5 daysuntil optimal dose was reached, was used as a rule unless severe side effects occurred. AmazonGlobal Ship Orders Internationally. Would you also like to submit a review for this item? Finally, the majority of aripiprazole patients the group with the longer time prior to discontinuation who quit treatment did so in the last phase of follow-up most of them reporting nonadherence. Four reasons for the discontinuation were recorded: However, formatting rules can vary widely between applications and fields of interest or study.


Second, the mean doses ruzi quetiapine used faforro be understood as somewhat low to treat first-episode individuals. Preventing relapse after a first episode of psychosis FEP is a critical aim to improve long-term outcome of the disease.

María Juncal-Ruiz

Insight and risk of suicidal behaviour in two first-episode psychosis cohorts: In those patients who continued taking the initial prescribed drug, mean antipsychotic doses at 3 years, adjusted in chlorpromazine equivalents, were aripiprazole, Previous studies investigating the effectiveness of different SGAs in the short Crespo-Facorro et al.

These concerns have been minimized by the results of large cohort studies published in recent years indicating that the use of antipsychotics is associated with a lower risk of death or severe health problem when compared with no use Vanasse et al.

Different effectiveness profiles among second-generation antipsychotics may be a key point to optimize treatment in patients suffering a first episode of psychosis to affect long-term outcome. Your list has reached the maximum number of items.

For commercial re-use, please contact journals. WorldCat is the world’s largest library catalog, helping you find library materials online.

To ensure group comparability, baseline sociodemographic and clinical characteristics were tested by 1-way ANOVA or Kruskal-Wallis test for continuous variables as necessary or by chi-squared test for qualitative variables. Social Psychiatry and Psychiatric Epidemiology.