Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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This dough then pressed through an extruder. We also use cookies on our websites. The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts. Application of Multiparticulate Technologies for Drug Delivery. Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format.

The Extrusion Spheronization Processs

The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. In other industries, the size of the pellets can be several centimeters. Please read our updated Cookies Policy for information about which cookies we use and the information we collect.

Just the way you need it. For technical reasons, the resulting pellets are larger than micrometers. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating. The dry, mixed, powdery active substances are kneaded into a dough with a liquid. Register for An Account Already a member?

The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.


Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets.

It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release. Cookies allow us to give you the best browsing experience and help us to understand how you use our site.

The process consists of five operations. By continuing to use this website, you agree that we may store and access cookies on your device. Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing spheronizaion be discussed with representative spheronizatiom studies. You can disable cookies but parts of our website may not work.

By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies. Please note that Lonza has updated its Privacy Policy. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications.

Our Mini-tablets are a popular finished dosage form extrjsion and offers the benefits of multiparticulates while using established tableting technology.

The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”.

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The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. The final drying ensures the pellet hardness. By Product Development Site. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying anx finished product.


Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales.

The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result. Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.

For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added. Primary packaging in spheeronization vials or sachets and secondary packaging services are also available.

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. Capsugel has sppheronization experience and capabilities in optimizing pediatric and multiparticulate extruusion.

The process consists of four process steps: By visiting our website or using services provided by Lonza, you are accepting the practices described in the Privacy Policy. Read more about it here! The ratio of liquid to solid material together with the size of the extruder holes spheronizatoon determines the quality of the extrudates. Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations.