Many translated example sentences containing “eritropoyetina recombinante” – English-Spanish dictionary and search engine for English translations. La farmacocinética de la eritropoyetina recombinante humana en pacientes con nefropatía endémica de los Balcanes. The Pharmacokinetics of Recombinant. Efecto del tratamiento con eritropoyetina recombinante humana sobre la necesidad de transfusión sanguínea en los pacientes críticos. Effect of human.
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Nonerythropoietin receptor-mediated pathways may play a major role.
Eritropoyetina Humana Recombinante Delta
When adjusted these differences remained statistically significant 0. This work is licensed under a Creative Commons Attribution 4. All works go through a rigorous selection process. Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis. The results were expressed as mean values with standard deviations.
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Erythropoietin and anemia in the progression of Balkan endemic nephropathy and other renal diseases. Faculty of Pharmacy, University of Belgrade, Serbia. Endemic nephropathy in Yugoslavia. Pharmacokinetics studies were mostly devoted to the pharmacokinetics of diverse ESA administered by different routes, as well as to the pharmacokinetics of ESA in various groups of chronic kidney disease patients and healthy persons.
Eur J Haematol ; Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: NDT Plus ;2 Suppl 1: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Pharmacokinetic analysis of beta-erythropoietin detected a significantly longer elimination half-life in BEN than in non BEN patients.
Clin J Am Soc Nephrol ;3: Previous article Next article.
However, several authors reported no significant differences between anemia in BEN and other kidney diseases. Si continua navegando, consideramos que acepta su uso. Inflammation and its impact on anaemia in chronic kidney disease: As previous studies showed that the kidneys contribute to Epo elimination in a very minor fashion 35 and residual kidney function in patients more than three years on dialysis is most often negligible, it is not expected that renal elimination of Recomibnante could be of any influence.
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J Pharm Sci ; Nine issues are published each year, including mostly originals, reviews and consensus documents. After beta-Epo administration plasma Epo slowly increased and C max was sritropoyetina after This item has received.
Eritropoyetina recombinante humana en la insuficiencia renal crónica
You can change the settings or obtain more information by clicking here. From Monday to Friday from 9 a. The Ethics Committee of the Clinical Center of Serbia evaluated and approved the study and the participants gave informed consent.
The journal accepts submissions of articles in English and in Spanish languages. Anemia was described as a characteristic of Balkan endemic nephropathy BEN in early reports on the disease, 1,2 so Danilovic 3 included it among the criteria for diagnosis.
It is governed by the peer review system and all original papers are subject to internal assessment and external reviews.
Srp arh cel lek ; The values of C max and t max are comparable to those found by other authors, taking into account the above mentioned differences in methodology. CiteScore measures average eritropoyetlna received per document published.
Therefore, not only the reitropoyetina by itself, but also the process of elimination and interaction directly with the Epo receptor on the red blood cell surface play an important role in increasing the values of Vd for Epo in comparison to its physiological distribution limited to extravascular space in the body. As the main organs involved in Epo elimination are the kidneys and bone marrow and both kidney function and bone marrow cellularity decrease with age, the authors suggested that age and creatinine influence Epo elimination.
These differences remained significant after adjustment for patient characteristics age, sex, hemodialysis duration, ferritin, PTH and ACEI use. Results The study involved 24 hemodialysis patients, 10 patients with BEN and 14 with other kidney diseases, selected from 96 patients 40 BEN and 56 others who met the inclusion criteria.