itwiki Encefalite letargica; nlwiki Encephalitis lethargica; plwiki Zapalenie mózgu von Economo; ptwiki Encefalite letárgica; ruwiki Летаргический энцефалит. Date, Source, von Economo C. Die Encephalitis lethargica (Mit zwölf lithographischen Tafeln). Franz Deuticke, ss. Leipzig-Wien. Translation for ‘encefalite letargica’ in the free Italian-English dictionary and many other English translations.

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The Berlin physician Werner Gottstein argued in his doctoral thesis published: The epidemiological situation lrtargica nicely encapsulated by David and Robert Thomson Pickett-Thomson Research Laboratory, Londonwho concluded their discussion of EL in an encyclopedic review of influenza thus:.

This is particularly true in light of the wncefalite finding that post-influenzal nervous symptoms manifested themselves within a few weeks of the onset of influenza for example, Marcus Caduceus Hong Kong ; 5: Altered reflex responses were less frequently encountered in EL, and often disappeared after only a few days.

Hawes, the curate in Agatha Christie ‘s book The Murder at the Vicaragewas described as suffering from this syndrome. The cerebrospinal fluid in epidemic encephalitis. After repeated questioning, the patient says that it is possible that he had experienced a mild grippe prior to the occurrence of his present complaints Baumann and de Leeuw The New York physician Sachs noted that in many cases, including the majority of those seen in consultation practice, a distinct episode of influenza had preceded the onset of the lethargic disorder by several weeks, similar to post-diphtheritic palsies which also occurred with a delay of weeks after the initial infection.

See the talk page for details. Eversbusch ; Galezowski ; Uhthoff The plot of Cemetery of Splendoura film by Apichatpong Weerasethakulrevolves around soldiers stricken with an epidemic of sleeping sickness.

EL, however, defied elucidation. Awakenings is a film starring Robin Williams and Robert De Niro which is the dramatization of real-life neurologist Oliver Sacks ‘ work with encephalitis lethargica patients.

Learn how and when to remove these template messages. But he also noted that:. Guizzetti similarly noted that autopsied EL cases did not present the tracheo-bronchial redness and swollen lymph nodes which were characteristic of the then prevalent influenza.

J Neurol Neurosurg Psychiat. But this recognition required time, as physicians became better acquainted with the disease and its victims in the course of years.


These early EL reports all pre-date the arrival in Europe of the first wave of pandemic influenza in Mayand occurred long before the deadly second wave of August-November J Nerv Ment Dis. Government Printing Office; Washington: Unsourced material may be challenged and removed. MuV Mumps Cytomegalovirus Cytomegalovirus esophagitis. Infectious diseases from nature: Although isolated cases of parkinsonism attributed to influenza have been described since the s pandemic, and despite the fact that the influenza A virus exhibits a certain tropism for the substantia nigra in laboratory animals Mattock et al ; Takahashi et al ; Yamada et al ; Casals et al ; Mihara et al ; Takahashi and YamadaEL-like symptoms have not been associated to any degree with influenza.

Even physicians who declared that they had never seen an EL patient without recent influenza regarded the two disorders as clinically distinguishable. Epidemic encephalitis and influenza; pp.

Some who shared his view nevertheless suspected that EL and influenza might be somehow related, just as measles and whooping cough were then regarded as allied disorders as they often occurred together in a population. Such letzrgica were, however, not pathognomic for EL, and were particularly familiar in diphtheria, as well as in influenza.

The disease is described in moderate detail in Peter Cummings’ novel The Neuropathology of Zombiesin which a proposed mutated form of the disease is considered as the possible cause of a ‘zombie’ outbreak.

Encephalitis lethargica – Wikipedia

Based on their extensive experience 81 cases at the Johns Hopkins HospitalHapp and Mason were assisted in the differentiation of the two diseases by the mode of onset of the disorder EL rarely announced itself as stormily as influenza encephalitisthe temperature course the rise in EL was more gradual and less severe and CSF analysis during the acute phase: This approach, however, is rendered impractical by inherent difficulties in estimating case numbers of these diseases.

This article has multiple issues. Letaegica was a very public letatgica, while EL was much stealthier; those who contracted influenza generally returned to full health within months, whereas survival of the acute phase of EL was often the segue to life-long debility.

Does the present volume solve the “riddle” of EL, which… has been referred to as the greatest medical mystery of the 20th century? There was typically letargicaa symptom-free interval between the acute and chronic stages of EL, but proposing that a similar interval existed between influenza infection and symptomatic EL encevalite purely speculative.


But as fresh EL cases continued to be diagnosed despite the passing of the influenza pandemic, the unitarian position lost ground, and was revived only after EL itself appeared to have vanished.

Note that a few countries have copyright terms longer than 70 years: The site of origin of the influenza pandemic and its public health implications.

Encephalitis lethargica EL L is a neuropsychiatric disorder which in recent times has occurred only once in epidemic form: Many of those who survived never returned to their pre-existing “aliveness”. This event was much cited by many during the EL period, but few appear to have noticed that Economo had been quick to correct his own early reference to this event.

In this respect it has often been observed that the first symptoms of general paralysis of the insane appeared to follow an attack of influenza.

It was also generally recognized that a proportion — perhaps the majority — of EL infections were undiagnosed or unreported see, for example, Neel ; Amsel Please review the contents of the article and add the appropriate references if you can. This image may not be in the public domain in these countries, which moreover do not implement the rule of the shorter term. In the most populous regions on Earth researchers identified only a handful of EL cases, and in neither India nor China did the distribution of cases concord with the course of the influenza pandemic for example: Grippe-Enzephalitis und Encephalitis lethargica.

encefalite letargica – English translation – Italian-English dictionary

D ICD – The Prague pathologist Franz Lucksch — reported that was no evidence in Germany for even a single person-to-person transmission of EL Lucksch As early ashowever, there were reports of multiple EL cases where no history of influenza could be established for instance: Die Encephalitis lethargica, ihre Nachkrankheiten und ihre Behandlung.

Studies on the etiology of epidemic encephalitis. Bacteriologischer Befund bei schweren Erkrankungen des Centralnervensystems im Verlauf von Influenza.