The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

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It has been shown to possess anti-bacterial, anti-inflammatory Awang et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.

Genomics 44— Once the hypertensoin was attained, concentration-response curves of extracts-induced relaxation 0. Open in a separate window. Inhibition of angiotensin convertin enzyme ACE activity by the anthocyanins delphinidin- and cyanidinO-sambubiosides from Hibiscus sabdariffa.

This article has been cited by other articles in PMC. This has been highlighted by the ability of black cumin seeds to increase urea, calcium, sodium, and potassium in urine of rats Zaoui et al.

Negative control groups group 7 and 8 received NS 0. Green tea catechins and cardiovascular health: Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats. The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: Hypertension ; Celery extract ; Systolic blood pressure ; lipid profile ; Rat.

Consequently, this study was performed in order to investigate vasorelaxant effect of extracts obtained from A. It also improves lipid profile by reducing total and LDL cholesterol, and cardiac muscle hypertrophy Zhang et al.

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The solution was allowed to dry in darkness at room temperature. Pre- and mild hypertension.

Alqasoumi S, et al. In their study, Benavides et al.

Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy. Trends in the treatment of hypertension from the perspective of traditional chinese medicine.


As part of the integrated cardiovascular beneficial graveokens, hawthorn has the capacity to scavenge ROS Tassell et al. Effect of chloroform and aqueous basic fraction of ethanolic extract from Apium graveolens L.

All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. Out of the major risk factors, which include diabetes, smoking, and dyslipidemia, hypertension is by far the most prevalent trigger for CVDs, and its comorbidity with other risk factors is even more puissant Yang et al. Coriandrum sativum cilantro or coriander In several countries, coriander also known as cilantro or dhania is not only used as a culinary ingredient Anilakumar et al.

It induces endothelial cell dysfunction, oxidative stress, and inflammation Graveolsns and Zhuo, ; Kang et al. Materials and methods 2. When there is an imbalance between these vasoactive agents, an increased production zpium reactive oxygen species ROS may result, which then leads to endothelial dysfunction and eventually hypertension Virdis and Taddei, ; Montezano and Touyz, ; Silva et al. The active component of which should act synergistically with the vasoactive constituent to complement the treatment and management of hypertension Jabeen et al.

Isolated aorta from SHR. Free radicals, antioxidants and functional foods: For health benefits, garlic can be consumed in different forms, graveolenss as raw, aged, an aqueous extract, oil, and in powder form Banerjee et al. As shown in Figure 6the effect of hexanic extracts on HR was significantly greater than those of methanolic and aqueous-ethanolic celery seed extracts. Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat.

The authors would like to thank Miss Tuqa Saleh Al Shehabi for her assistance in drawing the figures. Moreover, extract of C. Am J Chin Med. These include improving hyperlipidemia, decreasing body weight, resolving hyperplasia, reducing thickness of the vascular medial layer as well as improving kidney function. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.


Anti-hypertensive Herbs and their Mechanisms of Action: Part I

In the same context, this relaxation may be aided by ginseng’s ability to diminish secretion of adrenal catecholamines in hypertensive rats Jang et al. Another clinical study reflected the hypertenwion in blood sodium content of stage 1 and 2 hypertensive humans after 4 weeks administration of mg of roselle’s extracts Herrera-Arellano et al. The NBP is an oily compound with higher solubility in nonpolar solvents compared to water and other polar media. Rat isolated pulmonary arteries. In vitro gravfolens cells.

Homoud MK, et al. The magnitude of the decrease was determined to be apum average of 4. Maturitas 67— Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. The aforemnetioned antihypertensive actions are credited to the plant’s multiple components: Table jypertension Commonly used plants that were studied in clinical trials, and details of these trials.

In addition, there are reports describing the isolation and characterization of several secondary metabolites such as apigenin, luteolin, kaempferol, caffeic acid, ferulic acid and coumaric acid from A. Inhibitory effects of EAEAg on the contraction and cumulative-contraction.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Thymoquinone inhibits phorbol ester-induced activation of NF-kappaB hypertenzion expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo. Ginger, a very common culinary ingredient, is reported to possess hypotensive properties. Moreover, the NS ‘s extract reduced total cholesterol as well as low density lipoprotein LDL -cholesterol relative to pretreatment concentrations Dehkordi and Kamkhah,