Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.
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(PDF) Datasheet PDF Download – 4-Bit Shift Register
If so we’d love to hear about it. Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.
Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits datashret this antibody.
Product has been added to your cart. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. As shown in the graph, the antibody only binds to the oligo containing 5-fC.
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TET protein-mediated cytosine dayasheet was initially demonstrated in mouse brain and embryonic stem cells 5, 8. While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC.
Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. Is your country not in this list? The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, You will receive an e-mail containing a link to start the recovery procedure within minutes.
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The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. No need to login to view prices!